Most effective treatment options for Erectile Dysfunction

07.02.18 Posted By Nathaniel

Before understanding erection, let’s first understand the science behind erection, how it happens and what are regulating factors that contribute to erection. There are basically two mechanisms that manage the penile erection, one is through reflex erection that is by touching the organ and the other is through psychogenic erection in which there is a requirement of an arousal factor or sensual stimuli. In reflex erection the peripheral nerves and the lower region of the spinal cord are needed for a better erection while in Psychogenic erection the limbic system comes to play, in both, however, the role of a sound and the intact neuronal system is imperative. When the penile shaft is stimulated, the nervous system orders the release of Nitric oxide which leads to the relaxation of smooth muscles of Corpus Cavernosum of male genital thereby leading to an erection. In addition to this, a normal level of Testosterone and an intact pituitary gland is equally important for a healthy sensual functioning. For erectile dysfunction to happen there can be various factors such as hormonal deficiency, any disorder of or affecting the neuronal system, lack of proper blood supply, any psychological issue and any injury to the spinal cord. The blockade or restriction in blood circulation can also arise from any impairment in the endothelial function due to various heart issues such as coronary artery disease.

To treat Erectile Dysfunction there are multiple options available for a male such as penile implants, surgery etc. but one option that is most widely sought after is the use of oral medication. These drugs are used as the first line therapy for the management of ED. There are various brands that enclose the drugs of this class and are heavily used by males to get their erection back and perform better on the bed. Brands like Cenforce, Fildena, Viagra contain Sildenafil citrate as their active ingredient and brands like Vidalista and Cialis contain Tadalafil as its active ingredient, both these drugs belong to the same class and have a similar mechanism of action, they are both FDA approved and the difference is in the onset of action and duration of action.

Both Tadalafil and Sildenafil Citrate are PDE-5 inhibitors category medications. As the name denotes, these drugs exert therapeutic effects by blocking the action of an enzyme called PDE type 5. This enzyme has negative effects on erection as it disintegrates a chemical called cGMP which is needed for erection as it enhances the blood flow through the male genital by relaxing and dilating penile blood vessels. The cGMP levels are further augmented when the male body gets excited and releases nitric oxide which boosts up the production of the same.

Both these drugs are available in various brands such as Cenforce, Fildena, Filitra and Viagra as Sildenafil which is taken once a day, orally, about one hour before involving yourself in lovemaking. Brands such as Vidalista and Cialis contain Tadalafil which should be taken half an hour before making out; these drugs are taken once in three days. All these products should be taken in a sensually aroused state and with water.

Some adverse effects of this medication that can lead to inconvenience are a headache, muscle aches, back pain, heartburn, nasal blocking, vomiting, light-headedness and painful erection.


  • Do not take any PDE-5 inhibitor concomitantly with Nitrate medications as that can cause sudden and severe Hypotension which is a dangerous condition.
  • These drugs can make a few users feel drowsy, do not engage in any risky activity such as driving till you know how you respond to this medication.
  • These drugs are contraindicated in women and boys below 18 years of age.

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